diff --git a/client-cli/pvc/cli_lib/vm.py b/client-cli/pvc/cli_lib/vm.py
index bc6edaa0..c54b71b5 100644
--- a/client-cli/pvc/cli_lib/vm.py
+++ b/client-cli/pvc/cli_lib/vm.py
@@ -813,9 +813,9 @@ def vm_networks_add(config, vm, network, macaddr, model, sriov, sriov_mode, live
     return retcode, retmsg
 
 
-def vm_networks_remove(config, vm, network, sriov, live, restart):
+def vm_networks_remove(config, vm, network, macaddr, sriov, live, restart):
     """
-    Remove a network to the VM
+    Remove a network from the VM, optionally by MAC
 
     Calls vm_info to get the VM XML.
 
@@ -826,6 +826,9 @@ def vm_networks_remove(config, vm, network, sriov, live, restart):
     from lxml.objectify import fromstring
     from lxml.etree import tostring
 
+    if network is None and macaddr is None:
+        return False, "A network or MAC address must be specified for removal."
+
     status, domain_information = vm_info(config, vm)
     if not status:
         return status, domain_information
@@ -845,17 +848,26 @@ def vm_networks_remove(config, vm, network, sriov, live, restart):
         if sriov:
             if interface.attrib.get('type') == 'hostdev':
                 if_dev = str(interface.sriov_device)
-                if network == if_dev:
+                if macaddr is None and network == if_dev:
+                    interface.getparent().remove(interface)
+                    changed = True
+                elif macaddr is not None and macaddr == interface.mac.attrib.get('address'):
                     interface.getparent().remove(interface)
                     changed = True
             elif interface.attrib.get('type') == 'direct':
                 if_dev = str(interface.source.attrib.get('dev'))
-                if network == if_dev:
+                if macaddr is None and network == if_dev:
+                    interface.getparent().remove(interface)
+                    changed = True
+                elif macaddr is not None and macaddr == interface.mac.attrib.get('address'):
                     interface.getparent().remove(interface)
                     changed = True
         else:
             if_vni = re.match(r'[vm]*br([0-9a-z]+)', interface.source.attrib.get('bridge')).group(1)
-            if network == if_vni:
+            if macaddr is None and network == if_vni:
+                interface.getparent().remove(interface)
+                changed = True
+            elif macaddr is not None and macaddr == interface.mac.attrib.get('address'):
                 interface.getparent().remove(interface)
                 changed = True
         if changed:
@@ -866,8 +878,12 @@ def vm_networks_remove(config, vm, network, sriov, live, restart):
             new_xml = tostring(parsed_xml, pretty_print=True)
         except Exception:
             return False, 'ERROR: Failed to dump XML data.'
-    else:
+    elif not changed and network is not None:
         return False, 'ERROR: Network "{}" does not exist on VM.'.format(network)
+    elif not changed and macaddr is not None:
+        return False, 'ERROR: Interface with MAC "{}" does not exist on VM.'.format(macaddr)
+    else:
+        return False, 'ERROR: Unspecified error finding interface to remove.'
 
     modify_retcode, modify_retmsg = vm_modify(config, vm, new_xml, restart)
 
diff --git a/client-cli/pvc/pvc.py b/client-cli/pvc/pvc.py
index 7197a4ba..ee8d2f95 100755
--- a/client-cli/pvc/pvc.py
+++ b/client-cli/pvc/pvc.py
@@ -1541,7 +1541,11 @@ def vm_network_add(domain, net, macaddr, model, sriov_flag, sriov_mode, live_fla
     'domain'
 )
 @click.argument(
-    'net'
+    'net', required=False, default=None
+)
+@click.option(
+    '-m', '--mac-address', 'macaddr', default=None,
+    help='Remove an interface with this MAC address; required if NET is unspecified.'
 )
 @click.option(
     '-s', '--sriov', 'sriov_flag', is_flag=True, default=False,
@@ -1561,11 +1565,15 @@ def vm_network_add(domain, net, macaddr, model, sriov_flag, sriov_mode, live_fla
     help='Confirm the restart.'
 )
 @cluster_req
-def vm_network_remove(domain, net, sriov_flag, live_flag, restart_flag, confirm_flag):
+def vm_network_remove(domain, net, macaddr, sriov_flag, live_flag, restart_flag, confirm_flag):
     """
     Remove the network NET from the virtual machine DOMAIN.
 
     NET may be a PVC network VNI, which is added as a bridged device, or a SR-IOV VF device connected in the given mode.
+
+    NET is optional if the '-m'/'--mac-address' option is specified. If it is, then the specific device with that MAC address is removed instead.
+
+    If multiple interfaces are present on the VM in network NET, and '-m'/'--mac-address' is not specified, then all interfaces in that network will be removed.
     """
     if restart_flag and live_flag:
         click.echo('WARNING: Live flag and restart flag both specified; this can cause unintended behaviour. To disable live changes, use "--no-live".')
@@ -1577,7 +1585,7 @@ def vm_network_remove(domain, net, sriov_flag, live_flag, restart_flag, confirm_
         except Exception:
             restart_flag = False
 
-    retcode, retmsg = pvc_vm.vm_networks_remove(config, domain, net, sriov_flag, live_flag, restart_flag)
+    retcode, retmsg = pvc_vm.vm_networks_remove(config, domain, net, macaddr, sriov_flag, live_flag, restart_flag)
     cleanup(retcode, retmsg)